In vitro antimalarial activity of penduline, a bisbenzylisoquinoline from Isopyrum thalictroides | Zendy

Alexis Valentin | Zendy; Françoise Benoît-Vical | Zendy; Claire Moulis | Zendy; E Stanislas | Zendy; M. Mallié | Zendy; I. Fourasté | Zendy; J.-M. Bastide | Zendy

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In vitro antimalarial activity of penduline, a bisbenzylisoquinoline from Isopyrum thalictroides

Author(s) -

Alexis Valentin,

Françoise Benoît-Vical,

Claire Moulis,

E Stanislas,

M. Mallié,

I. Fourasté,

J.-M. Bastide

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.10.2305

Subject(s) - tetrandrine , in vitro , pharmacology , parasite hosting , biology , traditional medicine , malaria , medicine , immunology , biochemistry , world wide web , computer science

Two bisbenzylisoquinolines, tetrandrine and penduline, were purified from Isopyrum thalictroides. When tested for antimalarial activity in vitro, penduline was efficient at concentrations fivefold lower than those of tetrandrine. In highly synchronized parasite cultures, penduline mostly interfered between the 8th and the 32nd hours of the parasite cycle.

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