Low-level release of Shiga-like toxin (verocytotoxin) and endotoxin from enterohemorrhagic Escherichia coli treated with imipenem | Zendy

K. Takahashi | Zendy; K. Narita | Zendy; Yasuhiro Kato | Zendy; Tsuyoshi Sugiyama | Zendy; Naoki Koide | Zendy; Tomoaki Yoshida | Zendy; Takashi Yokochi | Zendy

Open Access

Low-level release of Shiga-like toxin (verocytotoxin) and endotoxin from enterohemorrhagic Escherichia coli treated with imipenem

Author(s) -

K. Takahashi,

K. Narita,

Yasuhiro Kato,

Tsuyoshi Sugiyama,

Naoki Koide,

Tomoaki Yoshida,

Takashi Yokochi

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.10.2295

Subject(s) - verocytotoxin , microbiology and biotechnology , escherichia coli , imipenem , shiga toxin , ceftazidime , antibiotics , shiga like toxin , toxin , biology , enterobacteriaceae , bacteria , pseudomonas aeruginosa , antibiotic resistance , biochemistry , genetics , gene

Shiga-like toxin (SLT) and endotoxin may participate in the pathogenesis of enterohemorrhagic Escherichia coli (EHEC) infection. Levels of release of SLT and endotoxin from EHEC treated in vitro with antibiotics were estimated. There were differential levels of release of SLT and endotoxin from EHEC treated with different antibiotics. Treatment of EHEC strains, namely, E. coli O157, O111, and O26, with imipenem induced much lower levels of release of SLT and endotoxin than treatment with ceftazidime.

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