Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica | Zendy

Serge Ankri | Zendy; Talia Miron | Zendy; A. Rabinkov | Zendy; Meir Wilchek | Zendy; David Mirelman | Zendy

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Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica

Author(s) -

Serge Ankri,

Talia Miron,

A. Rabinkov,

Meir Wilchek,

David Mirelman

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.10.2286

Subject(s) - allicin , entamoeba histolytica , hamster , cysteine , microbiology and biotechnology , baby hamster kidney cell , cysteine proteinase inhibitors , enzyme , chemistry , biology , biochemistry , cell , apoptosis , caspase , programmed cell death

The ability of Entamoeba histolytica trophozoites to destroy monolayers of baby hamster kidney cells is inhibited by allicin, one of the active principles of garlic. Cysteine proteinases, an important contributor to amebic virulence, as well as alcohol dehydrogenase, are strongly inhibited by allicin.

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