Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli | Zendy

T. Mizushima | Zendy; M. Matsuo | Zendy; Kazuhisa Sekimizu | Zendy

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Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli

Author(s) -

T. Mizushima,

M. Matsuo,

Kazuhisa Sekimizu

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.1.193

Subject(s) - groel , norfloxacin , escherichia coli , sparfloxacin , enoxacin , heat shock protein , ofloxacin , microbiology and biotechnology , chemistry , heat shock , levofloxacin , biology , biochemistry , antibiotics , ciprofloxacin , gene

Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for induction are similar to those required for DNA relaxation and much higher than those required for cell death.

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