Population pharmacokinetics of ganciclovir in newborns with congenital cytomegalovirus infections. NIAID Collaborative Antiviral Study Group | Zendy

Xiaojian Zhou | Zendy; William C. Gruber | Zendy; Gail J. Demmler | Zendy; R. F. Jacobs | Zendy; Peter D. Reuman | Zendy; S. P. Adler | Zendy; Mark Shelton | Zendy; Robert F. Pass | Zendy; Bill Britt | Zendy; J M Trang | Zendy; Richard J. Whitley | Zendy; JeanPierre Sommadossi | Zendy

Open Access

Population pharmacokinetics of ganciclovir in newborns with congenital cytomegalovirus infections. NIAID Collaborative Antiviral Study Group

Author(s) -

Xiaojian Zhou,

William C. Gruber,

Gail J. Demmler,

R. F. Jacobs,

Peter D. Reuman,

S. P. Adler,

Mark Shelton,

Robert F. Pass,

Bill Britt,

J M Trang,

Richard J. Whitley,

JeanPierre Sommadossi

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.9.2202

Subject(s) - pharmacokinetics , ganciclovir , population pharmacokinetics , cytomegalovirus , population , volume of distribution , medicine , pharmacodynamics , human cytomegalovirus , creatinine , cytomegalovirus infections , pharmacology , human immunodeficiency virus (hiv) , virology , virus , herpesviridae , viral disease , environmental health

The population pharmacokinetics of ganciclovir was investigated in a group of 27 newborns with symptomatic congenital cytomegalovirus infection by nonlinear mixed-effects modeling analysis. Individual characteristics including approximated creatinine clearance from serum (ASCC) and body weight (WGE) were identified to significantly influence total clearance from plasma (CL) and the apparent total volume of distribution (V) of ganciclovir, respectively. The regression equations used to model these relationships were expressed as CL (in liters per hour) = 0.262 + (0.00271 x ASCC) and V (in liters) = 0.627 + (0.437 x WGE). By using this model, typical values of the pharmacokinetic parameter CL and V were 0.428 +/- 0.079 liters/h and 1.773 +/- 0.320 liters, respectively. Upon validation with a larger number of newborns, this model should allow for the definition of possible relationships between the pharmacokinetic disposition of ganciclovir and pharmacodynamic events in neonates.

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