Gamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients | Zendy

Robert J. Sherertz | Zendy; Stephen O. Heard | Zendy; Issam Raad | Zendy; L Gentry | Zendy; David L. Bowton | Zendy; Philip Scuderi | Zendy; Jennifer Hu | Zendy; William Carruth | Zendy; B Satishchandra | Zendy; Judith Pepe | Zendy; Anne C. Mosenthal | Zendy; Thomas Burke | Zendy; J. Dupuis | Zendy

Open Access

Gamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients

Author(s) -

Robert J. Sherertz,

Stephen O. Heard,

Issam Raad,

L Gentry,

David L. Bowton,

Philip Scuderi,

Jennifer Hu,

William Carruth,

B Satishchandra,

Judith Pepe,

Anne C. Mosenthal,

Thomas Burke,

J. Dupuis

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.9.1995

Subject(s) - chlorhexidine , catheter , medicine , sterilization (economics) , intensive care unit , lumen (anatomy) , infection control , surgery , dentistry , intensive care medicine , monetary economics , economics , foreign exchange market , foreign exchange

In a randomized, double-blind trial, gamma radiation-sterilized, chlorhexidine-coated triple-lumen catheters were compared with uncoated control catheters for their ability to prevent catheter infection in 254 intensive care unit patients. The chlorhexidine coating was not efficacious, and a rabbit model demonstrated that reduction of chlorhexidine activity by gamma radiation sterilization was the likely explanation for the failure.

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