In vitro studies of two triazole antifungal agents (voriconazole [UK-109,496] and fluconazole) against Candida species | Zendy

A L Barry | Zendy; Steven D. Brown | Zendy

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In vitro studies of two triazole antifungal agents (voriconazole [UK-109,496] and fluconazole) against Candida species

Author(s) -

A L Barry,

Steven D. Brown

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.8.1948

Subject(s) - voriconazole , fluconazole , triazole , antifungal , microbiology and biotechnology , in vitro , biology , fungicide , pharmacology , chemistry , biochemistry , botany , organic chemistry

A new triazole derivative (voriconazole or UK-109,496) and fluconazole were tested against 249 isolates of Candida spp. representing six species. Voriconazole was 10 to 100 times more potent than fluconazole. Strains with decreased susceptibility to fluconazole were inhibited by relatively low concentrations of voriconazole.

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