Improved survival and antagonistic effect of sodium fusidate on tumor necrosis factor alpha in a neonatal mouse model of endotoxin shock | Zendy

Francesco Genovese | Zendy; Giuseppe Mancuso | Zendy; Maria Cuzzola | Zendy; V Cusumano | Zendy; Ferdinando Nicoletti | Zendy; Klaus Bendtzen | Zendy; Giuseppe Teti | Zendy

Open Access

Improved survival and antagonistic effect of sodium fusidate on tumor necrosis factor alpha in a neonatal mouse model of endotoxin shock

Author(s) -

Francesco Genovese,

Giuseppe Mancuso,

Maria Cuzzola,

V Cusumano,

Ferdinando Nicoletti,

Klaus Bendtzen,

Giuseppe Teti

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.7.1733

Subject(s) - tumor necrosis factor alpha , lipopolysaccharide , penicillin , sepsis , antibiotics , microbiology and biotechnology , septic shock , erythromycin , chloramphenicol , shock (circulatory) , gentamicin , pharmacology , salmonella , immunology , medicine , biology , bacteria , genetics

Unlike the antibiotics erythromycin and penicillin G, sodium fusidate (fusidin) pretreatment (80 mg/kg of body weight) increased the survival rate of neonatal BALB/c mice challenged with Salmonella enteritidis lipopolysaccharide. Fusidin also significantly reduced the plasma tumor necrosis factor alpha levels. Hence, fusidin may prove useful in the management of bacterial sepsis in humans.

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