Sequence and characterization of a novel chromosomal aminoglycoside phosphotransferase gene, aph (3')-IIb, in Pseudomonas aeruginosa | Zendy

Herbert Hächler | Zendy; P. Santanam | Zendy; F. H. Kayser | Zendy

Open Access

Sequence and characterization of a novel chromosomal aminoglycoside phosphotransferase gene, aph (3')-IIb, in Pseudomonas aeruginosa

Author(s) -

Herbert Hächler,

P. Santanam,

F. H. Kayser

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.5.1254

Subject(s) - phosphotransferase , aminoglycoside , pseudomonas aeruginosa , biology , gene , open reading frame , homology (biology) , microbiology and biotechnology , genetics , peptide sequence , nucleic acid sequence , antibiotics , bacteria

A novel, probably chromosomally encoded, aminoglycoside phosphotransferase gene was cloned on a 2,996-bp PstI fragment from Pseudomonas aeruginosa and designated aph (3')-IIb. It coded for a protein of 268 amino acids that showed 51.7% amino acid identity with APH (3')-II [APH(3') is aminoglycoside-3' phosphotransferase] from Tn5. Two other open reading frames on the cloned fragment showed homology to a signal-transducing system in P. aeruginosa.

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