GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin | Zendy

Martin Stieger | Zendy; Peter Angehrn | Zendy; Beatrice Wohlgensinger | Zendy; Hans Gmünder | Zendy

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GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin

Author(s) -

Martin Stieger,

Peter Angehrn,

Beatrice Wohlgensinger,

Hans Gmünder

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.4.1060

Subject(s) - novobiocin , dna gyrase , protein subunit , staphylococcus aureus , biology , microbiology and biotechnology , escherichia coli , gene , genetics , bacteria , antibiotics

The sequence of the gyrase B subunit gene from Staphylococcus aureus strains resistant to the gyrase B subunit inhibitors cyclothialidine, coumermycin, and novobiocin has been determined. The residues altered in the resistant gyrase B subunits map to the ATP-binding region, suggesting that the drugs inhibit ATP binding and hydrolysis. The pattern of cross-resistances indicates that the detailed binding mode of the compounds differs.

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