Influence of experimental rat model of multiple organ dysfunction on cefepime and amikacin pharmacokinetics | Zendy

Olivier Mimoz | Zendy; Anne Jacolot | Zendy; Christophe Padoin | Zendy; J Quillard | Zendy; Michel Tod | Zendy; K. Louchahi | Zendy; Kamran Samii | Zendy; Olivier Petitjean | Zendy

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Influence of experimental rat model of multiple organ dysfunction on cefepime and amikacin pharmacokinetics

Author(s) -

Olivier Mimoz,

Anne Jacolot,

Christophe Padoin,

J Quillard,

Michel Tod,

K. Louchahi,

Kamran Samii,

Olivier Petitjean

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.3.819

Subject(s) - cefepime , amikacin , pharmacokinetics , antibiotics , volume of distribution , pharmacology , medicine , distribution (mathematics) , organ dysfunction , biology , microbiology and biotechnology , sepsis , imipenem , mathematical analysis , mathematics , antibiotic resistance

We adapted an experimental model of multiple organ dysfunction to study the alterations it induces in the pharmacology of cefepime and amikacin. The half-lives of both antibiotics were significantly prolonged because of nonsignificant enhancement of the volume of distribution and reduced renal elimination. In the presence of multiple organ dysfunction, the concentration of each antibiotic in the lungs, compared with that in the lungs of healthy controls, was significantly decreased, despite similar concentrations in plasma, indicating that the application of a standard antibiotic concentration in plasma could lead to underdosage in tissues during the initial days of therapy.

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