In vitro activities of oxazolidinone compounds U100592 and U100766 against Staphylococcus aureus and Staphylococcus epidermidis | Zendy

Glenn W. Kaatz | Zendy; S M Seo | Zendy

Open Access

In vitro activities of oxazolidinone compounds U100592 and U100766 against Staphylococcus aureus and Staphylococcus epidermidis

Author(s) -

Glenn W. Kaatz,

S M Seo

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.3.799

Subject(s) - staphylococcus aureus , staphylococcus epidermidis , microbiology and biotechnology , antimicrobial , in vitro , minimum inhibitory concentration , staphylococcus , micrococcaceae , antibacterial agent , drug resistance , biology , antibiotics , medicine , chemistry , bacteria , biochemistry , genetics

The new oxazolidinone antimicrobial agents U100592 and U100766 demonstrated good in vitro inhibitory activity against clinical strains of Staphylococcus aureus and Staphylococcus epidermidis regardless of methicillin susceptibility. Both agents appeared bacteriostatic by time-kill analysis. Stable resistance to low multiples of the MIC of either drug could be produced only in methicillin-resistant S. aureus.

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