Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori | Zendy

James Versalovic | Zendy; Dee Shortridge | Zendy; K. Kibler | Zendy; M. V. Griffy | Zendy; Jill Beyer | Zendy; Robert K. Flamm | Zendy; Shinji Tanaka | Zendy; David Y. Graham | Zendy; M. F. Go | Zendy

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Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori

Author(s) -

James Versalovic,

Dee Shortridge,

K. Kibler,

M. V. Griffy,

Jill Beyer,

Robert K. Flamm,

Shinji Tanaka,

David Y. Graham,

M. F. Go

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.2.477

Subject(s) - 23s ribosomal rna , helicobacter pylori , clarithromycin , microbiology and biotechnology , biology , mutation , ribosomal rna , helicobacter , antibiotic resistance , genetics , antibiotics , gene , rna , ribosome

Twelve clarithromycin-resistant Helicobacter pylori isolates (100% of resistant isolates examined) from seven different patients each contained an A-->G transition mutation within a conserved loop of 23S rRNA. A-->G transition mutations at positions cognate with Escherichia coli 23S rRNA positions 2058 and 2059 were identified. Clarithromycin-susceptible H. pylori isolates from 14 different patients displayed no polymorphisms in a conserved loop within domain V of 23S rRNA. The study is the first to report mutations in H. pylori associated with resistance to an antimicrobial agent used in established peptic ulcer treatment regimens.

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