Some repair-deficient mutants of Dictyostelium discoideum display enhanced susceptibilities to bleomycin | Zendy

R. A. Deering | Zendy; Robert B. Guyer | Zendy; Levi Stevens | Zendy; T E Watson-Thais | Zendy

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Some repair-deficient mutants of Dictyostelium discoideum display enhanced susceptibilities to bleomycin

Author(s) -

R. A. Deering,

Robert B. Guyer,

Levi Stevens,

T E Watson-Thais

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.2.464

Subject(s) - dictyostelium discoideum , mutant , eukaryote , biology , bleomycin , dna , dna repair , dna damage , streptomyces , dictyostelium , mutation , slime mold , genetics , biochemistry , bacteria , gene , genome , chemotherapy

Dictyostelium discoideum, a soil eukaryote, is highly resistant to DNA-damaging agents; repair mutants are more susceptible. Susceptibility to bleomycin, produced by Streptomyces verticillus, is greater for mutants which are susceptible to other agents than for resistant strains. The high potential for DNA repair may result from the need to cope with chemicals produced by other soil microorganisms.

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