Activities against Streptococcus pneumoniae of amoxicillin and cefotaxime at physiological concentrations: in vitro pharmacodynamic simulation | Zendy

I P Balcabao | Zendy; L. Aguilar | Zendy; Marı́a Molina | Zendy; Yuliuva Hernández García | Zendy; Rafael Dal−Ré | Zendy; J. Prieto | Zendy

Open Access

Activities against Streptococcus pneumoniae of amoxicillin and cefotaxime at physiological concentrations: in vitro pharmacodynamic simulation

Author(s) -

I P Balcabao,

L. Aguilar,

Marı́a Molina,

Yuliuva Hernández García,

Rafael Dal−Ré,

J. Prieto

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.12.2904

Subject(s) - cefotaxime , amoxicillin , streptococcus pneumoniae , penicillin , microbiology and biotechnology , antibiotics , in vitro , streptococcaceae , antibacterial agent , pneumococcal infections , biology , biochemistry

An in vitro model simulating amoxicillin and cefotaxime concentrations in human serum (after standard doses) was used to explore the activities of these drugs over time against penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae strains. An initial inoculum reduction percentage of > or = 90% was obtained with amoxicillin and maintained for 2 to 8 h, regardless of the strain tested. In contrast, experiments showed that cefotaxime had significantly (P < 0.001) less capability to reduce initial inocula of the penicillin-resistant pneumococci from 0.5 h on than amoxicillin, despite the same in vitro susceptibility to amoxicillin and cefotaxime in both strains.

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