Identification of the tetracycline resistance gene, tet(O), in Streptococcus pneumoniae | Zendy

Carol A. Widdowson | Zendy; Keith P. Klugman | Zendy; D. Hanslo | Zendy

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Identification of the tetracycline resistance gene, tet(O), in Streptococcus pneumoniae

Author(s) -

Carol A. Widdowson,

Keith P. Klugman,

D. Hanslo

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.12.2891

Subject(s) - tetracycline , streptococcus pneumoniae , microbiology and biotechnology , campylobacter , biology , campylobacter jejuni , gene , streptococcaceae , nucleic acid sequence , campylobacter coli , antibacterial agent , genetics , bacteria , antibiotics

Five isolates of Streptococcus pneumoniae resistant to tetracycline but lacking tet(M) were studied. The tetracycline resistance gene, tet(O), was detected for the first time in the pneumococcus. The gene was amplified and sequenced and found to share 99% nucleotide sequence identity and 99, 99, and 98% deduced amino acid sequence identity with the tet(O) resistance genes of Streptococcus mutans, Campylobacter coli, and Campylobacter jejuni, respectively.

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