Prevalence of antimicrobial resistance among 723 outpatient clinical isolates of Moraxella catarrhalis in the United States in 1994 and 1995: results of a 30-center national surveillance study | Zendy

Gary V. Doern | Zendy; Angela B. Brueggemann | Zendy; Gary L. Pierce | Zendy; Timothy P. Hogan | Zendy; H. Preston Holley | Zendy; Alan Rauch | Zendy

Open Access

Prevalence of antimicrobial resistance among 723 outpatient clinical isolates of Moraxella catarrhalis in the United States in 1994 and 1995: results of a 30-center national surveillance study

Author(s) -

Gary V. Doern,

Angela B. Brueggemann,

Gary L. Pierce,

Timothy P. Hogan,

H. Preston Holley,

Alan Rauch

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.12.2884

Subject(s) - moraxella catarrhalis , cefpodoxime , cefixime , cefuroxime , microbiology and biotechnology , erythromycin , medicine , moraxella , azithromycin , trimethoprim , cefaclor , amoxicillin , moraxella (branhamella) catarrhalis , haemophilus influenzae , sulfamethoxazole , antibacterial agent , antibiotics , biology , cephalosporin , bacteria , genetics

Seven hundred twenty-three isolates of Moraxella catarrhalis obtained from outpatients with a variety of infections in 30 medical centers in the United States between 1 November 1994 and 30 April 1995 were characterized in a central laboratory. The overall rate of beta-lactamase production was 95.3%. When the National Committee for Clinical Laboratory Standards MIC interpretive breakpoints for Haemophilus influenzae were applied, percentages of strains found to be susceptible to selected oral antimicrobial agents were as follows: azithromycin, clarithromycin, and erythromycin, 100%; tetracycline and chloramphenicol, 100%; amoxicillin-clavulanate, 100%; cefixime, 99.3%; cefpodoxime, 99.0%; cefaclor, 99.4%; loracarbef, 99.0%; cefuroxime, 98.5%; cefprozil, 94.3%; and trimethoprim-sulfamethoxazole, 93.5%.

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