Effects of nifedipine and diltiazem on pharmacokinetics of cefpodoxime following its oral administration | Zendy

Antoine Deslandes | Zendy; F. Camus | Zendy; Christian Lacroix | Zendy; C Carbon | Zendy; Robert Farinotti | Zendy

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Effects of nifedipine and diltiazem on pharmacokinetics of cefpodoxime following its oral administration

Author(s) -

Antoine Deslandes,

F. Camus,

Christian Lacroix,

C Carbon,

Robert Farinotti

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.12.2879

Subject(s) - diltiazem , nifedipine , cefpodoxime , pharmacokinetics , oral administration , crossover study , pharmacology , drug interaction , absorption (acoustics) , volunteer , medicine , chemistry , antibacterial agent , calcium , antibiotics , biochemistry , alternative medicine , pathology , placebo , physics , acoustics , agronomy , biology

We compared the effects of nifedipine and diltiazem on the uptake of cefpodoxime proxetil (CP). The study was aimed at establishing the impact of increased mesenteric blood flow due to calcium channel blockers on passive transport. Twelve volunteers were given CP (200 mg) orally in a crossover design. The absorption, disposition, and elimination parameters of cefpodoxime were compared among the following three treatment groups: CP alone, CP following oral administration of diltiazem (60 mg), or CP following oral administration of nifedipine (20 mg). No statistically significant difference in pharmacokinetic parameters was observed between the three treatment groups.

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