Correlation of molecular resistance mechanisms and phenotypic resistance levels in streptomycin-resistant Mycobacterium tuberculosis | Zendy

A Meier | Zendy; Peter Sander | Zendy; K.J. Schaper | Zendy; Matthias Scholz | Zendy; Erik C. Böttger | Zendy

Open Access

Correlation of molecular resistance mechanisms and phenotypic resistance levels in streptomycin-resistant Mycobacterium tuberculosis

Author(s) -

A Meier,

Peter Sander,

K.J. Schaper,

Matthias Scholz,

Erik C. Böttger

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.11.2452

Subject(s) - streptomycin , mycobacterium tuberculosis , biology , microbiology and biotechnology , tuberculosis , phenotype , cross resistance , genetics , gene , antibiotics , medicine , pathology

Quantitative susceptibility testing of clinical isolates of streptomycin-resistant Mycobacterium tuberculosis demonstrated that there is a close correlation between the molecular resistance mechanism and the in vitro activity of streptomycin: mutations in rpsL were mainly associated with high-level resistance, mutations in rrs were associated with an intermediate level of resistance, and streptomycin-resistant isolates with wild-type rpsL and rrs exhibited a low-level resistance phenotype. Investigations of streptomycin-resistant isolates with wild-type rpsL and rrs revealed that (i) there is no cross-resistance to other drugs and (ii) a permeability barrier may contribute to resistance, because resistance was significantly lowered in the presence of a membrane-active agent.

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