Mechanism of selective inhibition of human immunodeficiency virus by ingenol triacetate | Zendy

Masatoshi Fujiwara | Zendy; K. Ijichi | Zendy; Kenji Tokuhisa | Zendy; Kimio Katsuura | Zendy; Shirô Shigeta | Zendy; K Konno | Zendy; G Y Wang | Zendy; Daisuke Uemura | Zendy; Tomoyuki Yokota | Zendy; Masanori Baba | Zendy

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Mechanism of selective inhibition of human immunodeficiency virus by ingenol triacetate

Author(s) -

Masatoshi Fujiwara,

K. Ijichi,

Kenji Tokuhisa,

Kimio Katsuura,

Shirô Shigeta,

K Konno,

G Y Wang,

Daisuke Uemura,

Tomoyuki Yokota,

Masanori Baba

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.1.271

Subject(s) - mechanism of action , viral replication , in vitro , chemistry , cytotoxicity , virus , cytotoxic t cell , human immunodeficiency virus (hiv) , virology , biology , biochemistry

Ingenol 3,5,20-triacetate (ITA), one of the ingenol derivatives, is a selective inhibitor of human immunodeficiency virus (HIV) replication in vitro. ITA inhibited the replication of HIV strains in MT-4 cells at concentrations of 0.051 to 0.65 microM. This concentration was approximately 10(3)-fold lower than its cytotoxic threshold. The mechanism of action of ITA is primarily attributed to the inhibition of viral adsorption to the host cells, but it is distinct from the mechanism of inhibition by other adsorption inhibitors.

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