Penicillin tolerance and modification of lipoteichoic acid associated with expression of vancomycin resistance in VanB-type Enterococcus faecium D366 | Zendy

Ludwig Gutmann | Zendy; S. Al-Obeid | Zendy; D Billot-Klein | Zendy; E Ebnet | Zendy; Werner Fischer | Zendy

Open Access

Penicillin tolerance and modification of lipoteichoic acid associated with expression of vancomycin resistance in VanB-type Enterococcus faecium D366

Author(s) -

Ludwig Gutmann,

S. Al-Obeid,

D Billot-Klein,

E Ebnet,

Werner Fischer

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.1.257

Subject(s) - lipoteichoic acid , enterococcus faecium , microbiology and biotechnology , lytic cycle , penicillin , vancomycin , lysis , biology , antibiotics , enterococcus , bacteria , chemistry , biochemistry , virology , staphylococcus aureus , virus , genetics

Induction of vancomycin resistance in Enterococcus faecium D366, which exhibits a VanB-type resistance, as well as its constitutive expression in MT9, a derivative of D366, was associated with penicillin tolerance as shown by decreased lysis and killing of the cells. This phenomenon was linked neither to decreased expression of the different autolysins nor to their decreased lytic activity on the different cell walls. The only change observed was that almost twice the normal amount of D-alanine was attached to the lipoteichoic acid.

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