Inhibitory effect of cephalothin on matrix metalloproteinase activity around loose hip prostheses | Zendy

Seppo Santavirta | Zendy; Michiaki Takagi | Zendy; Yrjö T. Konttinen | Zendy; Timo Sorsa | Zendy; Akio Suda | Zendy

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Inhibitory effect of cephalothin on matrix metalloproteinase activity around loose hip prostheses

Author(s) -

Seppo Santavirta,

Michiaki Takagi,

Yrjö T. Konttinen,

Timo Sorsa,

Akio Suda

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.1.244

Subject(s) - tetracycline , doxycycline , periprosthetic , chemistry , matrix metalloproteinase , metalloproteinase , matrix (chemical analysis) , biochemistry , surgery , medicine , arthroplasty , antibiotics , chromatography

The inhibitory effects of drugs on matrix metalloproteinase (MMP) activity in tissues around sites of loose total hip arthroplasty (THA) prostheses were studied. For activity measurements, a DNP-S (dinitrophenyl-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg) peptide degradation assay was performed by means of high-performance liquid chromatography. Neutral salt tissue extracts revealed significantly elevated MMP activity in THA samples compared with that in noninflamed synovial tissue from the knee joint. This elevation was markedly inhibited by cephalothin, but not by doxycycline, tetracycline, or gentamicin. These results indicate that cephalothin can inhibit MMP activity in reactive periprosthetic tissue and thus reduce, by a nonantimicrobial mechanism, the tissue destruction associated with the loosening of THA implants.

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