Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities | Zendy

Stefano Rusconi | Zendy; Mona Moonis | Zendy; Debra P. Merrill | Zendy; Peter V. Pallai | Zendy; Edith A. Neidhardt | Zendy; Sunit K. Singh | Zendy; Katherine Willis | Zendy; Marcia S. Osburne | Zendy; Albert T. Profy | Zendy; James C. Jenson | Zendy; M. S. Hirsch | Zendy

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Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities

Author(s) -

Stefano Rusconi,

Mona Moonis,

Debra P. Merrill,

Peter V. Pallai,

Edith A. Neidhardt,

Sunit K. Singh,

Katherine Willis,

Marcia S. Osburne,

Albert T. Profy,

James C. Jenson,

M. S. Hirsch

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.1.234

Subject(s) - toxoid , peripheral blood mononuclear cell , monocyte , zidovudine , virology , cell culture , chemistry , virus , biology , immunology , in vitro , biochemistry , tetanus , viral disease , vaccination , genetics

PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovudine, and do not inhibit tetanus toxoid-stimulated T-cell proliferation at anti-human immunodeficiency virus type 1 concentrations.

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