Ex vivo antibacterial properties of rufloxacin compared with those of norfloxacin in a study with healthy volunteers | Zendy

L. Aguilar | Zendy; I P Balcabao | Zendy; P Salvá | Zendy; Marı́a Molina | Zendy; José Galberto Martins da Costa | Zendy; J. Prieto | Zendy; Rafael Dal−Ré | Zendy

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Ex vivo antibacterial properties of rufloxacin compared with those of norfloxacin in a study with healthy volunteers

Author(s) -

L. Aguilar,

I P Balcabao,

P Salvá,

Marı́a Molina,

José Galberto Martins da Costa,

J. Prieto,

Rafael Dal−Ré

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.1.17

Subject(s) - norfloxacin , antibacterial agent , in vivo , antibiotics , ex vivo , pharmacology , medicine , microbiology and biotechnology , biology , ciprofloxacin

Twelve adult males participated in a randomized crossover phase I clinical trial comparing serum bactericidal titers (SBTs), urine bactericidal titers (UBTs), and urine killing rates (UKRs) against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 29213, after the administration of single 400-mg doses of rufloxacin and norfloxacin at different times up to 72 h postdose. SBTs were significantly higher (P 35 micrograms/ml), median UBTs (> 32 for E. coli and 16 for S. aureus) and UKRs for E. coli suggest prolonged urine antibacterial activity (for at least 72 h) and its use as a single 400-mg dose in the treatment of uncomplicated cystitis.

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