Open AccessTetracycline resistance mediated by ribosomal protection
Author(s) -
Diane E. Taylor,
Adolphus Kai-tung Chau
Publication year - 1996
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.40.1.1
Subject(s) - tetracycline , ribosomal rna , microbiology and biotechnology , biology , genetics , antibiotics , gene
Resistance to tetracycline may be mediated by one of three different mechanisms: (i) an energy-dependent efflux of tetracycline brought about by an integral membrane protein (20); (ii) ribosomal protection by a soluble protein (5, 23), or (iii) enzymatic inactivation of tetracycline (33), which occurs rarely. This minireview concentrates exclusively on the second mechanism of tetracycline resistance.
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