Effect of Rifampin on Cutaneous Hypersensitivity to Purified Protein Derivative in Humans | Zendy

P Mukerjee | Zendy; Sandra S. Schuldt | Zendy; John E. Kasik | Zendy

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Effect of Rifampin on Cutaneous Hypersensitivity to Purified Protein Derivative in Humans

Author(s) -

P Mukerjee,

Sandra S. Schuldt,

John E. Kasik

Publication year - 1973

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.4.6.607

Subject(s) - purified protein derivative , delayed hypersensitivity , derivative (finance) , hypersensitivity reaction , immunology , antibiotics , medicine , pharmacology , tuberculosis , microbiology and biotechnology , biology , tuberculin , antigen , pathology , economics , financial economics

The effect of rifampin on cutaneous hypersensitivity was studied in 11 tuberculous patients. A suppressive effect was noted in eight patients, five of whom developed a negative response to the strength of purified protein derivative to which they had been shown to be previously sensitive. In one instance complete anergy to purified protein derivative was noted. It appears that rifampin has immunosuppressive effects in some patients when used in conventional doses.

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