Open AccessEffect of Racephenicol on Antibiotic Resistance of Lactose-Fermenting Enteric Bacteria in Chickens
Author(s) -
Larry D. Rollins,
Dorothy W. Pocurull,
Steven Reynolds
Publication year - 1973
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.4.3.277
Subject(s) - chloramphenicol , microbiology and biotechnology , salmonella , oxytetracycline , lactose , ampicillin , dihydrostreptomycin , biology , escherichia coli , antibiotics , bacteria , enterobacteriaceae , fermentation , virginiamycin , enteric bacteria , streptomycin , food science , biochemistry , genetics , gene
The incidence of lactose-fermenting enteric organisms resistant to chloramphenicol increased from less than 0.1% prior to treatment to more than 90% in two groups of chickens fed racephenicol-supplemented feed at 50 or 140 g/ton for 10 days, whereas controls remained unchanged. A concurrent increase in the incidence of organisms resistant to dihydrostreptomycin, oxytetracycline, ampicillin, and sulfonamides also occurred. Minimum inhibitory concentrations for chloramphenicol increased from 300 μg/ml in mostEscherichia coli isolates in response to treatment. The observed resistance was transferable toE. coli andSalmonella .