Bactericidal Effect of Combinations of Nalidixic Acid and Various Antibiotics on Enterobacteriaceae | Zendy

J. Michel | Zendy; R. Luboshitzky | Zendy; T. Sacks | Zendy

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Bactericidal Effect of Combinations of Nalidixic Acid and Various Antibiotics on Enterobacteriaceae

Author(s) -

J. Michel,

R. Luboshitzky,

T. Sacks

Publication year - 1973

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.4.3.201

Subject(s) - nalidixic acid , antagonism , antimicrobial , enterobacteriaceae , antibiotics , microbiology and biotechnology , gentamicin , colistin , kanamycin , biology , chemistry , antibiotic resistance , escherichia coli , biochemistry , receptor , gene

The activity of nalidixic acid combined with each of 10 other antimicrobial agents on 95 strains of Enterobacteriaceae was studied. Synergism was found less often than antagonism, and the commonest outcome was indifference. Combinations of nalidixic acid with kanamycin, gentamicin, or colistin were more often synergistic than antagonistic, whereas with the other antibiotics the combination was more often antagonistic than synergistic. Synergistic effects were more common with Shigella than with other genera. In vitro examination for synergism or antagonism appears to be advisable before nalidixic acid is used therapeutically in combination with other antimicrobial agents.

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