Comparative In Vitro Activity of Three Aminoglycosidic Antibiotics: BB-K8, Kanamycin, and Gentamicin | Zendy

Pauline K. W. Yu | Zendy; John A. Washington | Zendy

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Comparative In Vitro Activity of Three Aminoglycosidic Antibiotics: BB-K8, Kanamycin, and Gentamicin

Author(s) -

Pauline K. W. Yu,

John A. Washington

Publication year - 1973

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.4.2.133

Subject(s) - gentamicin , kanamycin , enterococcus faecalis , microbiology and biotechnology , providencia , penicillin , proteus , carbenicillin , antibiotics , nalidixic acid , enterobacteriaceae , proteus mirabilis , streptococcus , pseudomonas aeruginosa , chemistry , biology , staphylococcus aureus , bacteria , escherichia coli , ampicillin , biochemistry , genetics , gene

Kanamycin, BB-K8, and gentamicin were tested in parallel against 1,037 bacterial strains isolated from clinical material. The activity of BB-K8 at 20 μg/ml was comparable to that of gentamicin at 8 μg/ml againstPseudomonas aeruginosa and againstEnterobacteriaceae , with the exception of gentamicin-resistant strains ofProteus rettgeri andProvidencia stuartii , in which case the activities of BB-K8 and kanamycin were the same. BB-K8 exhibited little or no activity against streptococci. The activity of BB-K8 was affected by pH and inoculum size. A regression graph for inhibition data with a 10-μg disk of BB-K8 was developed, and synergistic activity of penicillin and BB-K8 againstStreptococcus faecalis was tested.

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