Open AccessComparative In Vitro Activity of Three Aminoglycosidic Antibiotics: BB-K8, Kanamycin, and Gentamicin
Author(s) -
Pauline K. W. Yu,
John A. Washington
Publication year - 1973
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.4.2.133
Subject(s) - gentamicin , kanamycin , enterococcus faecalis , microbiology and biotechnology , providencia , proteus , penicillin , carbenicillin , antibiotics , nalidixic acid , enterobacteriaceae , streptococcus , pseudomonas aeruginosa , proteus mirabilis , chemistry , biology , bacteria , staphylococcus aureus , escherichia coli , ampicillin , biochemistry , genetics , gene
Kanamycin, BB-K8, and gentamicin were tested in parallel against 1,037 bacterial strains isolated from clinical material. The activity of BB-K8 at 20 μg/ml was comparable to that of gentamicin at 8 μg/ml againstPseudomonas aeruginosa and againstEnterobacteriaceae , with the exception of gentamicin-resistant strains ofProteus rettgeri andProvidencia stuartii , in which case the activities of BB-K8 and kanamycin were the same. BB-K8 exhibited little or no activity against streptococci. The activity of BB-K8 was affected by pH and inoculum size. A regression graph for inhibition data with a 10-μg disk of BB-K8 was developed, and synergistic activity of penicillin and BB-K8 againstStreptococcus faecalis was tested.