Open AccessIn vitro effects of sulfadiazine and its metabolites alone and in combination with pyrimethamine on Toxoplasma gondii
Author(s) -
E Schoondermark-van de Ven,
T. B. Vree,
Willem J. G. Melchers,
W Camps,
J M Galama
Publication year - 1995
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.39.3.763
Subject(s) - sulfadiazine , pyrimethamine , toxoplasma gondii , in vitro , toxoplasmosis , pharmacology , microbiology and biotechnology , chemistry , biology , biochemistry , antibiotics , virology , chloroquine , immunology , malaria , antibody
Sulfadiazine and the metabolites N4-acetyl-sulfadiazine, 4-OH-sulfadiazine, 5-OH-sulfadiazine, 5-OH-glucuronide-sulfadiazine, and 5-OH-sulfate-sulfadiazine were tested separately and in combination with pyrimethamine for the inhibitory activity on Toxoplasma gondii growth in vitro. Except for N4-acetyl-sulfadiazine, all sulfa compounds possessed anti-Toxoplasma activity. The addition of 0.05 micrograms of pyrimethamine per ml, a concentration which in itself is not inhibitory, potentiated the microbial activity of sulfadiazine and its metabolites 100 fold.
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