Open AccessInhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate
Author(s) -
Lin Guo,
Nina K. Heinzinger,
Mario Stevenson,
Lawrence M. Schopfer,
James M. Salhany
Publication year - 1994
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.38.10.2483
Subject(s) - in vitro , pyridoxal , pyridoxal phosphate , pyridoxal 5 phosphate , human immunodeficiency virus (hiv) , phosphate , potency , lysine , biochemistry , antagonist , chemistry , biology , virology , enzyme , amino acid , receptor , cofactor
Pyridoxal 5'-phosphate and related compounds were tested for their ability to inhibit gp120-CD4 interaction and human immunodeficiency virus infection in vitro. The results show that pyridoxal 5'-phosphate is a unique CD4 antagonist whose antiviral potency derives from the presence of both lysine-reactive and anionic substituents.