Open AccessEfficacies of different vancomycin dosing regimens against Staphylococcus aureus determined with a dynamic in vitro model
Author(s) -
Stephen B. Duffull,
Evan J. Begg,
Stephen T. Chambers,
Murray L. Barclay
Publication year - 1994
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.38.10.2480
Subject(s) - dosing , staphylococcus aureus , vancomycin , in vitro , minimum inhibitory concentration , antibiotics , antibacterial agent , staphylococcus , pharmacology , microbiology and biotechnology , medicine , chemistry , biology , bacteria , biochemistry , genetics
A dynamic in vitro model was used to assess four different vancomycin dosing regimens against Staphylococcus aureus. These regimens achieved peak drug concentrations of 48 micrograms/ml (single dose) and 30 micrograms/ml (dosed every 12 h) and constant concentrations of 16 and 8 micrograms/ml. Analysis of the area under the bacterial concentration-time curve, area under the first moment of the bacterial concentration-time curve, and bacterial elimination rate constant showed no difference in the rate or extent of bacterial killing. The optimal dosing method may be that which achieves the lowest area under the curve while concentrations are maintained above the MBC.