Lincosamide antibiotics stimulate dissociation of peptidyl-tRNA from ribosomes | Zendy

John R. Menninger | Zendy; R A Coleman | Zendy

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Lincosamide antibiotics stimulate dissociation of peptidyl-tRNA from ribosomes

Author(s) -

John R. Menninger,

R A Coleman

Publication year - 1993

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.37.9.2027

Subject(s) - lincomycin , ribosome , transfer rna , peptidyl transferase , antibiotics , ribosomal rna , erythromycin , protein biosynthesis , microbiology and biotechnology , biochemistry , biology , chemistry , rna , gene

At nonpermissive temperatures the peptidyl-tRNA hydrolase of pth(Ts) bacterial mutants is inactivated, and cells accumulate peptidyl-tRNA and die. Doses of erythromycin, lincomycin, or clindamycin that inhibited the growth of antibiotic-hypersensitive DB-11 pth+ cells accelerated the killing of DB-11 pth(Ts) cells at nonpermissive temperatures. Erythromycin and lincomycin also stimulated the accumulation of peptidyl-tRNA. Lincomycin and clindamycin stimulated peptidyl-tRNA dissociation from ribosomes.

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