Clarithromycin, minocycline, and rifabutin treatments before and after infection of C57BL/6 mice with Mycobacterium avium | Zendy

Thierry Lazard | Zendy; C. Perronne | Zendy; J Grosset | Zendy; J. L. Vildé | Zendy; J J Pocidalo | Zendy

Open Access

Clarithromycin, minocycline, and rifabutin treatments before and after infection of C57BL/6 mice with Mycobacterium avium

Author(s) -

Thierry Lazard,

C. Perronne,

J Grosset,

J. L. Vildé,

J J Pocidalo

Publication year - 1993

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.37.8.1690

Subject(s) - rifabutin , clarithromycin , minocycline , antibiotics , medicine , antibacterial agent , mycobacterium , microbiology and biotechnology , spleen , mycobacterium avium intracellulare infection , gastroenterology , immunology , biology , pathology , tuberculosis

C57BL/6 mice were pretreated with rifabutin or clarithromycin alone or combined with minocycline 3 days before intravenous challenge (day 0) with Mycobacterium avium. Treatment was continued until sacrifice at days 1, 8, 15, and 21. Rifabutin or clarithromycin decreased the level of infection in both the lungs and the spleen. Rifabutin was as effective as clarithromycin in the lungs but was less [corrected] effective in the spleen. The clarithromycin-minocycline combination was as effective as clarithromycin alone.

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