In vitro antibacterial activity and beta-lactamase stability of CP-70,429 a new penem antibiotic | Zendy

M Minamimura | Zendy; Y Taniyama | Zendy; E Inoue | Zendy; S Mitsuhashi | Zendy

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In vitro antibacterial activity and beta-lactamase stability of CP-70,429 a new penem antibiotic

Author(s) -

M Minamimura,

Y Taniyama,

E Inoue,

S Mitsuhashi

Publication year - 1993

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.37.7.1547

Subject(s) - citrobacter freundii , enterobacter cloacae , microbiology and biotechnology , pseudomonas aeruginosa , antibacterial activity , stenotrophomonas maltophilia , antibiotics , enterobacter , antibacterial agent , bacteria , xanthomonas , beta lactamase , gram negative bacteria , enterobacteriaceae , biology , in vitro , beta lactamase inhibitors , chemistry , escherichia coli , biochemistry , genetics , gene

In in vitro susceptibility tests, the new penem CP-70,429 showed potent antibacterial activity against gram-positive and gram-negative bacteria except Pseudomonas aeruginosa and Xanthomonas maltophilia. CP-70,429 was stable to various types of beta-lactamases except for the enzyme from X. maltophilia and was 16- to 128-fold more active than the other compounds against beta-lactamase-producing strains of Enterobacter cloacae and Citrobacter freundii.

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