Role of cephalosporinase in carbapenem resistance of clinical isolates of Pseudomonas aeruginosa | Zendy

Xiaoming Zhou | Zendy; Marie-Dominique Kitzis | Zendy; Ludwig Gutmann | Zendy

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Role of cephalosporinase in carbapenem resistance of clinical isolates of Pseudomonas aeruginosa

Author(s) -

Xiaoming Zhou,

Marie-Dominique Kitzis,

Ludwig Gutmann

Publication year - 1993

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.37.6.1387

Subject(s) - pseudomonas aeruginosa , imipenem , microbiology and biotechnology , biology , pseudomonadaceae , carbapenem , pseudomonadales , antibiotics , bacteria , antibiotic resistance , genetics

With numerous imipenem-resistant clinical isolates of Pseudomonas aeruginosa as well as in vitro-selected resistant mutants, we have demonstrated, by a simple method with a powerful cephalosporinase inhibitor, BRL42715, the contribution of chromosomal cephalosporinase in resistance to imipenem in this species.

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