Susceptibilities of serial Cryptococcus neoformans isolates from patients with recurrent cryptococcal meningitis to amphotericin B and fluconazole | Zendy

Arturo Casadevall | Zendy; Eric D. Spitzer | Zendy; Douglas Webb | Zendy; Michael G. Rinaldi | Zendy

Open Access

Susceptibilities of serial Cryptococcus neoformans isolates from patients with recurrent cryptococcal meningitis to amphotericin B and fluconazole

Author(s) -

Arturo Casadevall,

Eric D. Spitzer,

Douglas Webb,

Michael G. Rinaldi

Publication year - 1993

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.37.6.1383

Subject(s) - cryptococcus neoformans , fluconazole , amphotericin b , microbiology and biotechnology , cryptococcus , meningitis , cryptococcosis , cryptococcal meningitis , drug resistance , antibiotics , biology , medicine , antifungal , immunology , human immunodeficiency virus (hiv) , viral disease , surgery

Amphotericin B and fluconazole susceptibilities of 13 Cryptococcus neoformans isolates from five patients with recurrent cryptococcal meningitis were determined. For each patient, serial isolates showed no increase in antibiotic resistance relative to the initial isolate. For these patients, recurrent disease was not due to drug resistance but may reflect changes in immune function and/or poor compliance.

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