Open AccessEfficacy of (-)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine in African green monkeys infected with simian varicella virus
Author(s) -
Kenneth F. Soike,
R Böhm,
Junli Huang,
Bo Öberg
Publication year - 1993
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.37.6.1370
Subject(s) - virology , viremia , guanine , hydroxymethyl , dose , virus , inoculation , simian , rash , intramuscular injection , biology , african green monkey , medicine , pharmacology , immunology , chemistry , stereochemistry , biochemistry , nucleotide , gene
(-)-9-[4-Hydroxy-2-(hydroxymethyl)butyl]guanine was evaluated for its efficacy in African green monkeys infected with simian varicella virus. Treatment by intramuscular injection was initiated 48 h after virus inoculation and was continued for 10 days; the treatment showed therapeutic effects on rash and viremia at dosages down to 1 mg/kg of body weight per day.