Efficacy of (-)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine in African green monkeys infected with simian varicella virus | Zendy

Kenneth F. Soike | Zendy; Rudolf Bohm | Zendy; Junli Huang | Zendy; B. Öberg | Zendy

Open Access

Efficacy of (-)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine in African green monkeys infected with simian varicella virus

Author(s) -

Kenneth F. Soike,

Rudolf Bohm,

Junli Huang,

B. Öberg

Publication year - 1993

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.37.6.1370

Subject(s) - virology , viremia , guanine , hydroxymethyl , virus , dose , inoculation , rash , simian , simian immunodeficiency virus , chickenpox , intramuscular injection , biology , african green monkey , medicine , pharmacology , immunology , chemistry , stereochemistry , biochemistry , nucleotide , gene

(-)-9-[4-Hydroxy-2-(hydroxymethyl)butyl]guanine was evaluated for its efficacy in African green monkeys infected with simian varicella virus. Treatment by intramuscular injection was initiated 48 h after virus inoculation and was continued for 10 days; the treatment showed therapeutic effects on rash and viremia at dosages down to 1 mg/kg of body weight per day.

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