Open AccessEffects of interleukin-8 on nonspecific resistance to infection in neutropenic and normal mice
Author(s) -
M.T.E. Vogels,
I. J. D. Lindley,
J.H.A.J. Curfs,
W. M. C. Eling,
J.W.M. van der Meer
Publication year - 1993
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.37.2.276
Subject(s) - pseudomonas aeruginosa , neutropenia , plasmodium berghei , klebsiella pneumoniae , immunology , interleukin , cytokine , microbiology and biotechnology , biology , medicine , chemotherapy , bacteria , malaria , escherichia coli , biochemistry , genetics , gene
The effect of treatment with interleukin-8 (IL-8), a neutrophil-activating cytokine, was investigated in normal and neutropenic mice infected with a lethal dose of Pseudomonas aeruginosa, Klebsiella pneumoniae, or Plasmodium berghei. Intraperitoneal (i.p.) IL-8 treatment was associated with accelerated death when IL-8 was administered shortly before i.p. infection with P. aeruginosa or shortly after i.p. infection with P. aeruginosa and K. pneumoniae. Histopathological analyses demonstrated a tendency to more severe organ lesions in IL-8-treated mice. Only nonneutropenic mice that received IL-8 shortly before the infectious challenge and at the site of infection were protected by IL-8. Whether IL-8 is protective of or detrimental to the survival of infection appeared to depend on the presence of bacteria at the injection site and on the presence of neutropenia. IL-8 may be an important participant in the cascade of interacting cytokines that is induced by the lethal infectious challenge.