Open AccessAugmentation of murine tumor necrosis factor production by amphotericin B in vitro and in vivo
Author(s) -
Yoshiko Tokuda,
Masakatsu Tsuji,
Masatoshi Yamazaki,
Sadao Kimura,
Shigeru Abe,
Hideyo Yamaguchi
Publication year - 1993
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.37.10.2228
Subject(s) - in vivo , tumor necrosis factor alpha , amphotericin b , lipopolysaccharide , in vitro , microbiology and biotechnology , tumor necrosis factor α , necrosis , biology , priming (agriculture) , immunology , pharmacology , medicine , pathology , antifungal , biochemistry , botany , germination
Murine peritoneal macrophages were preincubated with amphotericin B (AMPH) and were then stimulated with bacterial lipopolysaccharide or streptococcal preparation (OK432). These macrophages produced a large amount of tumor necrosis factor. When administered to mice, the priming activity of amphotericin B for tumor necrosis factor production in vivo was also observed.