Open AccessCandidicidal activity of the human recombinant myeloperoxidase system
Author(s) -
Christophe Tournay,
Patrick Majerus,
Michel Pourtois,
Nicole Moguilevsky,
Alex Bollen
Publication year - 1993
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.37.1.142
Subject(s) - myeloperoxidase , recombinant dna , candida albicans , enzyme , microbiology and biotechnology , enzyme assay , biology , biochemistry , chemistry , immunology , gene , inflammation
The effect of the human recombinant myeloperoxidase (recMPO) system on the viability of Candida albicans blastospores was determined. Cells were incubated in the presence of the enzyme, H2O2, and various substrates. In optimal conditions, 100% mortality was reached with only 41 mU of recMPO per ml, confirming its powerful candidicidal activity.