Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter | Zendy

Alexander A. Neyfakh | Zendy; C M Borsch | Zendy; Glenn W. Kaatz | Zendy

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Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter

Author(s) -

Alexander A. Neyfakh,

C M Borsch,

Glenn W. Kaatz

Publication year - 1993

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.37.1.128

Subject(s) - efflux , staphylococcus aureus , bacillus subtilis , transporter , microbiology and biotechnology , multiple drug resistance , staphylococcus , biology , atp binding cassette transporter , drug resistance , bacteria , gene , biochemistry , genetics

The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. subtilis multidrug transporter protein Bmr does. NorA and Bmr share 44% sequence similarity. Both the NorA- and Bmr-conferred resistances can be completely reversed by reserpine.

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