Bacteriostatic and bactericidal activities of gentamicin alone and in combination with clarithromycin against Mycobacterium avium | Zendy

Leonid Heifets | Zendy; Pamela J. Lindholm-Levy | Zendy; R. Dawn Comstock | Zendy

Open Access

Bacteriostatic and bactericidal activities of gentamicin alone and in combination with clarithromycin against Mycobacterium avium

Author(s) -

Leonid Heifets,

Pamela J. Lindholm-Levy,

R. Dawn Comstock

Publication year - 1992

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.36.8.1695

Subject(s) - gentamicin , clarithromycin , microbiology and biotechnology , antibacterial agent , mycobacterium avium intracellulare infection , antibiotics , minimum inhibitory concentration , mycobacterium , aminoglycoside , biology , bacteria , genetics

The inhibitory activity of gentamicin against Mycobacterium avium depended on the pH of the medium, and the broth-determined MICs for 90% of strains were 5.0 micrograms/ml at pH 7.4, 9.5 micrograms/ml at pH 6.8, and greater than 16.0 micrograms/ml at pH 5.0. The MBCs were two- to eightfold higher than the MICs. The combined effect of gentamicin and clarithromycin was additive, and the MICs and MBCs of each drug were either the same as those in the single-drug tests or reduced twofold.

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