Stability of meropenem and effect of 1 beta-methyl substitution on its stability in the presence of renal dehydropeptidase I | Zendy

MASATOMO FUKASAWA | Zendy; Yoshihiro Sumita | Zendy; E.T. Harabe | Zendy; Tomoharu Tanio | Zendy; HIROSHI NOUDA | Zendy; Tsuneo Kohzuki | Zendy; T. OKUDA | Zendy; Hideaki Matsumura | Zendy; Masataka Sunagawa | Zendy

Open Access

Stability of meropenem and effect of 1 beta-methyl substitution on its stability in the presence of renal dehydropeptidase I

Author(s) -

MASATOMO FUKASAWA,

Yoshihiro Sumita,

E.T. Harabe,

Tomoharu Tanio,

HIROSHI NOUDA,

Tsuneo Kohzuki,

T. OKUDA,

Hideaki Matsumura,

Masataka Sunagawa

Publication year - 1992

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.36.7.1577

Subject(s) - meropenem , imipenem , chemistry , antibacterial agent , pharmacology , antibiotics , biology , stereochemistry , biochemistry , antibiotic resistance

The stability of meropenem in the presence of renal dehydropeptidase I (DHP-I) varied extremely with the animal source of the enzyme. Meropenem, compared with imipenem, was rather easily hydrolyzed by DHP-Is from mice, rabbits, and monkeys, while it showed a higher resistance to guinea pig and beagle dog DHP-Is. In addition, meropenem was four times more resistant than imipenem to human DHP-I. The 1 beta-methyl substituent on carbapenems, i.e., meropenem and 1 beta-methyl imipenem, made them considerably more resistant to mouse and swine DHP-Is than the 1-unsubstituted derivatives are.

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