In vitro studies of activities of some antifungal agents against Candida albicans ATCC 10231 by the turbidimetric method | Zendy

M. T. Blanco | Zendy; C. PérezGiraldo | Zendy; J Blanco | Zendy; F.J. Morán | Zendy; C. Hurtado | Zendy; A.C. Gómez-Garcı́a | Zendy

Open Access

In vitro studies of activities of some antifungal agents against Candida albicans ATCC 10231 by the turbidimetric method

Author(s) -

M. T. Blanco,

C. PérezGiraldo,

J Blanco,

F.J. Morán,

C. Hurtado,

A.C. Gómez-Garcı́a

Publication year - 1992

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.36.4.898

Subject(s) - miconazole , ketoconazole , bifonazole , clotrimazole , candida albicans , flucytosine , amphotericin b , itraconazole , pharmacology , biology , corpus albicans , growth inhibition , minimum inhibitory concentration , antifungal drug , antifungal drugs , microbiology and biotechnology , antifungal , in vitro , chemistry , antimicrobial , biochemistry

Different criteria (the drug concentration which inhibited 50% of growth [IC1/2], the lowest drug concentration at which growth was just less than 30% of that in a positive control well [IC30], the visual inhibitory concentration [ICv], and the minimum fungicidal concentration [MFC]) were applied to study the effects of some antifungal agents against Candida albicans. Amphotericin B, flucytosine, and bifonazole produced total growth inhibition. Clotrimazole, itraconazole, ketoconazole, and miconazole produced partial growth inhibition. The values of IC1/2 and IC30 were similar for all agents and avoided the problems of partial inhibition; the values of ICv and MFC were higher than those of IC1/2 and IC30.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research