Open AccessA pneumococcal clinical isolate with high-level resistance to cefotaxime and ceftriaxone
Author(s) -
A. M. S. Figueiredo,
James D. Connor,
Anatoly Severin,
M. V. Vaz Pato,
Alexander Tomasz
Publication year - 1992
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.36.4.886
Subject(s) - cefotaxime , ceftriaxone , streptococcus pneumoniae , benzylpenicillin , microbiology and biotechnology , penicillin , serotype , pneumococcal infections , streptococcaceae , meningitis , antibiotics , cephalosporin , penicillin binding proteins , medicine , antibacterial agent , biology , surgery
A beta-lactam-resistant serotype 23F Streptococcus pneumoniae clinical isolate from the cerebrospinal fluid of a pediatric patient from California is unusual in that the MICs of cefotaxime and ceftriaxone (2.5 micrograms/ml each) are higher than that of benzylpenicillin (0.3 micrograms/ml); the isolate also has patterns of penicillin-binding proteins and of cell wall peptides which are atypical compared with those of previously examined penicillin-resistant pneumococci.