Open AccessIn vitro activity of E1040 against imipenem-resistant Pseudomonas aeruginosa strains
Author(s) -
Masato Watanabe,
Eiko Inoue,
Kanemasa Katsu,
Shizuko Iyobe,
Susumu Mitsuhashi
Publication year - 1992
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.36.3.684
Subject(s) - imipenem , pseudomonas aeruginosa , microbiology and biotechnology , pseudomonadaceae , pseudomonadales , in vitro , strain (injury) , pseudomonas , biology , beta lactamase , enzyme , chemistry , bacteria , antibiotics , antibiotic resistance , biochemistry , escherichia coli , gene , genetics , anatomy
E1040 showed the most potent activity (MIC for 90% of strains, 6.25 micrograms/ml) among beta-lactams tested against 70 strains of imipenem-resistant Pseudomonas aeruginosa. Two strains showed high-level resistance to E1040; one strain produced a type II oxyiminocephalosporin-hydrolyzing beta-lactamase (group 3), and the other produced an enzyme similar to a type II penicillinase (OXA-1). Both beta-lactamases contributed to resistance to E1040.