In vitro activity of E1040 against imipenem-resistant Pseudomonas aeruginosa strains | Zendy

Masato Watanabe | Zendy; E Inoue | Zendy; K Katsu | Zendy; Shizuko Iyobe | Zendy; S Mitsuhashi | Zendy

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In vitro activity of E1040 against imipenem-resistant Pseudomonas aeruginosa strains

Author(s) -

Masato Watanabe,

E Inoue,

K Katsu,

Shizuko Iyobe,

S Mitsuhashi

Publication year - 1992

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.36.3.684

Subject(s) - imipenem , pseudomonas aeruginosa , microbiology and biotechnology , pseudomonadaceae , pseudomonadales , in vitro , strain (injury) , pseudomonas , biology , beta lactamase , enzyme , chemistry , bacteria , antibiotics , antibiotic resistance , biochemistry , escherichia coli , gene , genetics , anatomy

E1040 showed the most potent activity (MIC for 90% of strains, 6.25 micrograms/ml) among beta-lactams tested against 70 strains of imipenem-resistant Pseudomonas aeruginosa. Two strains showed high-level resistance to E1040; one strain produced a type II oxyiminocephalosporin-hydrolyzing beta-lactamase (group 3), and the other produced an enzyme similar to a type II penicillinase (OXA-1). Both beta-lactamases contributed to resistance to E1040.

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