Assay of fluconazole by high-performance liquid chromatography with a mixed-phase column | Zendy

Jack Wallace | Zendy; S.C. Harris | Zendy; John C. Gallegos | Zendy; George Foulds | Zendy; T J Chen | Zendy; Michael G. Rinaldi | Zendy

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Assay of fluconazole by high-performance liquid chromatography with a mixed-phase column

Author(s) -

Jack Wallace,

S.C. Harris,

John C. Gallegos,

George Foulds,

T J Chen,

Michael G. Rinaldi

Publication year - 1992

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.36.3.603

Subject(s) - chromatography , pharmacokinetics , fluconazole , cerebrospinal fluid , high performance liquid chromatography , coefficient of variation , chemistry , phase (matter) , antifungal , pharmacology , medicine , microbiology and biotechnology , biology , organic chemistry

A mixed-phase liquid chromatographic column was used to assay fluconazole in plasma, serum, and cerebrospinal fluid. The assay was linear from 0.2 to 20 micrograms/ml, with an average coefficient of variation of less than 5%. The partitioning of the drug between serum and cerebrospinal fluid was determined for 34 patients. The method was demonstrated to be suitable for both pharmacokinetic studies and monitoring of patients receiving treatment with this antifungal agent.

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