Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential | Zendy

Kimmo Suomalainen | Zendy; Timo Sorsa | Zendy; L M Golub | Zendy; N. Ramamurthy | Zendy; H M Lee | Zendy; V J Uitto | Zendy; H Saari | Zendy; Y T Konttinen | Zendy

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Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential

Author(s) -

Kimmo Suomalainen,

Timo Sorsa,

L M Golub,

N. Ramamurthy,

H M Lee,

V J Uitto,

H Saari,

Y T Konttinen

Publication year - 1992

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.36.1.227

Subject(s) - doxycycline , collagenase , pharmacology , fibroblast , anti inflammatory , chemistry , microbiology and biotechnology , antibiotics , enzyme , medicine , biology , biochemistry , in vitro

The concentrations of doxycycline and 4-de-dimethylaminotetracycline required to inhibit 50% of collagenase activity were found to be 15 to 30 microM for human neutrophil and gingival crevicular fluid collagenases. Fibroblast collagenase was relatively resistant to inhibition by tetracyclines; the 50% inhibitory concentrations of doxycycline and 4-de-dimethylaminotetracycline were 280 and 510 microM, respectively.

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