Susceptibility of Pneumocystis carinii to artemisinin in vitro | Zendy

Salim Merali | Zendy; Steve Meshnick | Zendy

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Susceptibility of Pneumocystis carinii to artemisinin in vitro

Author(s) -

Salim Merali,

Steve Meshnick

Publication year - 1991

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.35.6.1225

Subject(s) - artemisinin , pneumocystis carinii , in vitro , protozoa , microbiology and biotechnology , biology , virology , plasmodium falciparum , immunology , malaria , human immunodeficiency virus (hiv) , biochemistry , pneumocystis jirovecii

The susceptibility of Pneumocystis carinii to artemisinin (qinghaosu) was determined in short-term primary culture. In untreated cultures, trophozoites increased an average of fivefold over 4 days. Inhibition of parasite growth in cultures treated with artemisinin at concentrations as low as 0.5 microM was seen. In contrast, artemisinin concentrations up to 100 microM had no effect on feeder layer cells.

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